Working with solitary-molecule optical and AFM imaging and force-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
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Back in 1991, Sumio Iijima from the NEC Corporation had reported the synthesis of carbon nanotubes. Band framework calculations instructed that these nanotubes could show metallic band conduction. This may be a big edge in excess of the conducting polymers we had explored, which have been, actually, disordered semiconductors providing simply variable-assortment hopping conductivity.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2010, developed a brand new way (‘wedging transfer’) to manipulate nanostructures; 1st report of DNA translocation as a result of graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into strong-state nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
Many associated developments followed, in which our group set up distinct transistor variants which include one-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled numerous transistors into tiny proof-of-principle Digital circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim of the pore is highlighted in purple, and a 3D rendering of your motion with the DNA rod ceesdekker.net is displayed.
Imagine if, as an alternative to using regular best-down silicon electronics, transistors can be created from the bottom up employing single organic and natural molecules as the switching things? This idea, which grew to become The premise of nowadays’s industry of molecular electronics, very first emerged while in the nineteen seventies.
There was a single dilemma while — we didn't notice any measurable electrical conduction from the single polymer molecules. We concluded that at The one-molecule amount, conducting polymers were being actually not this kind of fantastic conductors, which was fairly disappointing. We Hence broadened our look at to try to discover more promising molecules.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, to start with demonstration of molecular sorting inside a lab over a chip using biomotors; discovery of nanobubbles in strong-condition nanopores; and to start with estimate of electrokinetic energy conversion within a nanofluidic channel
By way of example, we consider the nucleopore complicated, a gateway among the mobile nucleus plus the cytoplasm. This is an extremely complex system and as a consequence tough to research inside of a mobile, so we use biomimetics. We reconstruct holes then insert person elements with the nucleopore sophisticated to review transport by it at the single-molecule amount.’
It absolutely was an extremely fascinating time, through which I received a great deal of help from Delft College of Technologies, in which I was a professor at time, and I started out several collaborations with molecular biologists. That assisted me study quite a bit.’